SEARCH

 

Mission

Research
CTA
The final goal of medical imaging is the optimization of the acquisition, reconstruction and processing of (bio) medical images aiming to ameliorate in a multidisciplinary effort the diagnosis and therapy of patients and the understanding of clinical and fundamental biological processes.
The evolution in imaging acquisition modalities (CT, MR, US, PET, SPECT, ...) yields an explosion of image information that becomes hard to analyse in detail. New tracers and contrast agents are introduced for the visualisation of biological characteristics of the individual patient ("personalised medicine"). New opportunities are created by development in mathematics, computer sciences, evolution in hard- and software. For the extraction of relevant clinical and biological information, new techniques of image analysis, image quantification and image archiving are introduced. Most efforts of medical imaging are focussed mainly on the diseases of the century, i.e. cancer (screening, diagnosis and follow-up), neurodegenerative diseases (movement disorders and dementia), epilepsy and brain tumours, and heartand blood vessel diseases (diagnosis and therapy).
In this context there is a growing interest of clinicians of different specialties for integration of multimodal imaging in clinical pathways and decision trees. There is an increasing demand of the authorities to limit the budget and to place the diagnostic possibilities in the context of "evidence based medicine". At the same time medical imaging opens new diagnostic tools for fundamental biological research trying to find new molecular targets for diagnosis and therapy. Molecular imaging can also stimulate the cooperation between academia and industry for the development of new drugs on diagnostic tracers.
The challenges and the opportunities of medical imaging in UZ Leuven are evident:
  • International imaging research center in the heart of a 1800 bed university hospital
  • Faster interdisciplinary exchange of research information
  • Creation of a platform for multidisciplinary cooperation projects
  • Faster access to critical data
  • A perfectfusion of research and clinical care
  • An efficient platform for translational research
  • Better qualitative clinical care as the ultimate result
This multidisciplinary research approach can be situated on three levels:
  • Image formation:
    • Image modalities: CTA
      • Quality assessment of digital mammography.
      • Potential of low dose CT for diagnosis and therapy planning and contrast agents (lung cancer screening, 3D oral imaging, virtual colonoscopy)
    • Strain rate imaging with cardiac ultrasound.
    • Tracers and contrast agents:
      • Tumor characterisation with multispectral MRI
      • Tumor characterisation with PET (FDG, FLT, FMISO)
    • Image quality enhancement
      • Model based reconstruction of PET and CT
CTA Ablation
  • Image computing:
    • Automated image analysis:
      • Image registration: multimodality fusion of CT and NMR; comparing pre and posttreatment PET
      • Image segmentation
      • Modeling anatomical shape and shape variability
    • 3D visualisation:
      • Computer aided diagnosis for colorectal cancer screening
      • Subtraction CT angiography
      • Electro-anatomical mapping of cardiac arrhythmias
    • Quantification of morphology and function
      • Automated lung measurements in thorax RX
      • Quantification of regional wall stress
      • Kinetic modelling with PET
  • Clinical application:
    • Neurology:
      • Visualisation of brain connectivity with diffusion tensor MRI
      • Multimodality imaging for epilepsy surgery planning
      • Imaging of neurodegeneration of prestage Alzheimer
      • In vivo imaging of novel neurochemical targets
    • Cardiology:
      • Assessment of myocardial infarction and residual viability
    • Oncology:
      • Non invasive assessment of cancer therapies
      • Image guided radiotherapy
    • Molecular imaging
CTA CTA